Gamete intrafallopian transfer (GIFT)

What is it?

This form of assisted reproduction technique involves the same first and second step as IVF, namely superovulation and monitoring follicular and endometrial growth. The eggs are retrieved by ultrasound-guided-aspiration of the follicles on the ovaries. The eggs and a sperm sample are then places together in a catheter. In step four, a laparoscopy is performed on the patient and the eggs and sperm are injected into the fallopian tube via the catheter.

Although the process places the egg and sperm in close proximity that enhances the chance of collision, it does not guarantee fertilisation.

When is it appropriate?

The process is used to bypass physical barriers to normal egg and sperm transport due to adhesions, endometriosis, and immunological problems.

Requirements:

• At least 1 million sperm cells per millilitre after preparation.
• At least 1 normal Fallopian tube.
• The production of 3 or more oocytes.

1. Hormone treatment (superovulation) to ensure the development of several oocytes.
2. Monitoring of follicular growth.
3. Induction of ovulation.
4. The sperm sample is prepared approximately 2 hours before the aspiration of the oocytes.
5. Laparoscopic (which involves general anaesthetic) aspiration of oocytes.
6. Transfer of 3 (mature) oocytes plus a sample of sperm into the upper part of the fallopian tube.
7. Pregnancy test (day 12, after transfer).

Number of visits to clinic: 7 to 10 per cycle

Success rate:

About 40% per treatment cycle. See benchmark results for more information.